A and C, Ca2+ transients evoked by capsaicin (0.5 μM, 30 s) before, during and 15 min after 5-min treatments of HDM (50 μg/ml) + U73122 (1 μM) and HDM (50 μg/ml) + chelerythrine (10 μM), respectively. B and D, group data showing that the effect of HDM was completely prevented by U73122 (P > 0.05, n = 19) and chelerythrine (P > 0.05, n = 15), respectively.