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. 2012 Mar 8;3:32. doi: 10.3389/fphar.2012.00032

Figure 1.

Figure 1

A metabolism-centric interaction network for Sir2. (A) Network of 84 direct interactors of Sir2; the 40 genes associated with the GO term “metabolism” and/or “carbohydrate metabolism” are highlighted in blue or purple, respectively. (See Table A1 in Appendix for GO terms associated with these Sir2 interactors). (B) The network (A) expanded with the direct interactors of the 40 genes with annotated metabolic function. This network containing first and second order metabolism related Sir2 interactors interconnects with 2888 vertices half of the yeast proteome. We apologize that due to this complexity, not all genes names may be readable. (A,B) Physical- and genetic-interactors for Sir2 were obtained from the BioGrid database as of December 2011 and illustrated with OSPrey (Stark et al., 2006).