Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Innate immunity and mitochondria in PD. Many PARK related gene products are located in mitochondria, implicating mitochondrial dysfunction in PD. Interestingly, MAVS/VISA that are attached to the outer membrane of mitochondria are involved in viral infection signaling by activating TRAF6 and TRAF5. Phosphorylation of Iκβα and IRF-3 leads to nuclear translocation of transcription factors and the production of cytokines.
