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. 2012 Mar;37(2):113–121. doi: 10.1503/jpn.110038

Fig. 1.

Fig. 1

Assessment of tonic activation of D2 receptors in the prefrontal cortex (PFC). Integrated firing rate histograms of PFC pyramidal neurons illustrating systemic administration of the D2 receptor antagonist haloperidol (HAL; 0.2 mg/kg) in (A) rats subjected to saline (controls) and (B) rats receiving a 14-day regimen of pramipexole (PPX; 1 mg/kg/d). Each bar corresponds to 50-second application of dopamine (DA), and the number above each bar corresponds to the ejection current in nA. The arrow indicates a point of injection of 200 μg/kg of haloperidol. (C) The overall effect of systemic administration of haloperidol on baseline firing of PFC pyramidal neurons in controls and rats receiving PPX (expressed as % of change in basal firing). **p = 0.002.