Table 1.

Overall association (using family-based association tests) between the 30 tag single-nucleotide polymorphisms within SLC6A2 and attention-deficit/hyperactivity disorder

Marker no.	RS number	Location	Major allele (allele 1)	Minor allele	No. of informative families*	Z statistic (allele 1)	p value
1	rs28386840	Upstream promoter	A	T	147	0.71	0.48
2	rs4783899	5′flanking	G	T	183	−1.69	0.09
3	rs1362621	5′flanking	A	G	148	1.13	0.26
4	rs2397771	5′flanking	G	C	173	1.85	0.06
5	rs168924	5′flanking	T	C	106	0.41	0.68
6	rs2242446	5′flanking	T	C	152	0.95	0.34
7	rs3785143	Intron 1	C	T	76	2.25	0.024
8	rs192303	Intron 1	G	C	156	1.11	0.27
9	rs41154	Intron 1	A	G	169	−1.76	0.08
10	rs187715	Intron 2	A	G	41	0.61	0.54
11	rs36024	Intron 3	C	T	166	1.33	0.18
12	rs187714	Intron 3	T	C	173	−1.55	0.12
13	rs36023	Intron 3	C	T	170	0.58	0.56
14	rs36021	Intron 3	T	A	163	2.64	0.008
15	rs3785152	Intron 3	C	T	73	1.46	0.14
16	rs1814269	Intron 3	G	A	162	−1.66	0.10
17	rs36017	Intron 3	C	G	166	−1.53	0.13
18	rs10521329	Intron 4	C	A	116	0.00	> 0.99
19	rs3785155	Intron 4	G	A	94	0.03	0.98
20	rs5564	Intron 5	T	C	46	1.27	0.20
21	rs11568324	Intron 5	C	T	11	0.58	0.56
22	rs2279805	Intron 6	T	C	170	−1.43	0.15
23	rs8047672	Intron 8	G	A	119	−0.08	0.94
24	rs5569	Exon 9	C	T	153	1.72	0.08
25	rs998424	Intron9	C	T	151	1.76	0.08
26	rs36009	Intron 10	G	A	55	0.77	0.44
27	rs1800887	Intron 11	T	C	131	1.16	0.25
28	rs2242447	Intron 13	T	C	160	1.15	0.25
29	rs15534	Exon 14	C	T	102	0.76	0.45
30	rs7188230	3′intergenic	A	G	124	0.84	0.40

^*The number of informative families varies for each tag single-nucleotide polymorphism, depending on the heterozygocity of the marker.