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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Future Med Chem. 2012 Feb;4(2):227–243. doi: 10.4155/fmc.11.190

Table 1.

Key characteristics of pharmacokinetic treatments for drug addiction.

Characteristic Peripheral blocker (antibody) Increased drug metabolism
Active immunity Passive immunity Enzyme Catalytic antibody
Onset of action Weeks to months Immediate Immediate Immediate
Duration of action Months Days Days Days
Specificity of action Very high Very high High Very high
Control over treatment agent Low High High High
Possibility of saturating binding sites Medium Medium Low Low
Likely clinical use Addiction Toxicity/overdose Toxicity/overdose Toxicity/overdose