TABLE 2.
LUNG FUNCTION OF COHORT
| Study Subcohort |
Subcohort Biomarkers Available* |
|||||||
| Baseline Never-smokers | Cases FEV1 Less Than LLN | Control Subjects FEV1 Greater Than or Equal to LLN | Cases Less Than LLN | Control Subjects Greater Than or Equal to LLN | P Value† | |||
| N | 801 | 109 | 218 | 71 | 166 | |||
| FEV1‡ | Pre 9/11 | % | 100 (91–109) | 89 (82–96) | 108 (98–118) | 88 (82–96) | 108 (98–117) | <0.0001 |
| L | 4.3 (3.8–4.8) | 3.8 (3.5–4) | 4.5 (4–5) | 3.8 (3.5–4.2) | 4.5 (4–5.1) | <0.0001 | ||
| MME | % | 90 (82–100) | 78 (72–88) | 97 (89–107) | 77 (71– 88) | 96 (89–106) | <0.0001 | |
| L | 3.8 (3.4–4.3) | 3.4 (3.4) | 4 (3.6–4.6) | 3.3 (3.1–3.7) | 4.1 (3.6–4.5) | <0.0001 | ||
| SPE | % | 94 (84–102) | 73 (67–76) | 106 (93–112) | 73 (68–76) | 104 (93–112) | <0.0001 | |
| L | 3.9 (3.5–4.3) | 3 (2.7–3) | 4.2 (3.7–4.7) | 3.1 (2.8–3.3) | 4.2 (3.7–4.6) | <0.0001 | ||
| FEV1/FVC | SPE | 78 (74–82) | 73 (65–77) | 79 (75–83) | 72 (65–77) | 79 (75–82) | <0.0001 | |
Definition of abbreviations: LLN = lower limit of normal as defined by NHANES III; NHANES = National Health and Nutrition Examination Survey; MME = medical monitoring entry; SPE = subspecialty pulmonary examination.
*
Available serum biomarkers and all measures of metabolic syndrome.
†
P values determined by Mann-Whitney except exposure P value determined by Pearson chi-square; between cases and control subjects of subcohort biomarkers available.
‡
Values expressed as medians (interquartile range).