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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2012 January-February;1(1):153–165. doi: 10.1002/wdev.9

Figure 2.

Figure 2

Generalized schematic of the BMP signaling pathway.

Type I and type II BMP receptors span the cell membrane and bind extracellular BMP ligand. Ligand binding to receptor complexes activates signaling through type II receptor phosphorylation of the type I receptor at the GS domain. Type I receptor phsophorylation is accompanied by reduced GS binding by proteins, such as FKBP1A, that regulate receptor signaling in the absence of ligand binding. Activated type I receptor phosphorylates cytoplasmic signal transduction proteins such as R-SMADs and MAPKs, which in turn, directly or indirectly regulate transcription of target genes in the nucleus.

[Reprinted from Shore and Kaplan, Nature Reviews Rheumatology 2010, 6,518–527.]