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. 2012 Feb;46(2):196–206. doi: 10.1165/rcmb.2011-0071OC

Figure 6.

Figure 6.

LRP-1 regulates uPA-dependent migration in PMCs. (A) Serum-starved MeT5A cells were incubated in the presence or absence of RAP for 15 minutes at room temperature. Cells were placed on vitronectin-coated filter inserts in the presence or absence of uPA and allowed to migrate at 37°C for 6 hours. Cells were then fixed, stained, and counted. This experiment was repeated twice (n = 3 determinations per group in each experiment). Data from a representative experiment are illustrated. (B) Serum-starved HPMCs cells were incubated in the presence or absence of RAP for 15 minutes at room temperature. Cells were then placed on vitronectin-coated filter inserts in the presence or absence of uPA and allowed to migrate at 37°C for 6 hours. Cells were fixed, stained, and counted (n = 3 determinations per group in each experiment). Data from a representative experiment are illustrated. *P < 0.05 when compared with PBS controls. $P < 0.05 when compared with uPA.