Table 3.

Adjusted ^a hazard ratios (HR) of additional time to breast cancer events and all-cause mortality in relation to quality of life in a cohort of US breast cancer survivors followed for a mean of 7.3 years (n = 2967)

		Additional breast cancer events b			All-cause mortality c
Variable d (Quintile)	n	Event	HR (95%CI)	P trend	Event	HR (95%CI)	P trend
Physical Health
0 –57.5	588	121	Reference		87	Reference
57.6 –76.3	610	116	0.94 (0.71,1.23)		71	0.85 (0.61,1.19)
76.4 – 85.6	595	88	0.67 (0.50,0.91)	0.005	59	0.71 (0.49,1.04)	0.004
85.7 – 91.9	578	71	0.53 (0.37,0.75)		40	0.51 (0.33,0.80)
92 – 100	594	96	0.71 (0.50,1.00)		44	0.58 (0.36,0.92)
Mental Health
0 – 63.3	593	114	Reference		74	Reference
63.3 –76.7	593	106	1.05 (0.79,1.39)	0.41	69	1.03 (0.73,1.45)	0.32
76.8 – 85	603	87	0.91 (0.67,1.23)		46	0.82 (0.55,1.23)
85.1 – 90.5	592	91	1.07 (0.78,1.47)		56	1.16 (0.78,1.74)
90.6 –100	584	94	1.21 (0.85,1.72)		56	1.26 (0.81,1.98)
Hostility
0	608	86	Reference		59	Reference
1 – 1	884	71	1.04 (0.76,1.44)	0.03	42	0.86 (0.57,1.29)	0.94
2 –3	712	124	1.05 (0.79,1.39)		78	0.91 (0.64,1.29)
4 –5	460	109	1.40 (1.05,1.88)		60	0.95 (0.65,1.38)
6 –13	290	99	1.24 (0.92,1.68)		61	0.93 (0.64,1.36)

^aThe additional breast cancer events and all-cause mortality model were both adjusted for age at randomization, race/ethnicity, menopausal status, tumor type, tumor grade, tumor stage, anti-estrogen use, clinical sites, time between cancer diagnosis and study entry, physical activity, hot flashes, randomization status, and interaction between hot flashes and randomization status. All-cause mortality model was additionally adjusted for marital status.

^bAdditional breast cancer events is the time from study enrollment to development of an additional breast cancer event.

^cAll-cause mortality is the time from enrollment to reported/confirmed death from all causes.

^dSee text for details regarding the measurements scales.