Table 1.
Summary of the structural information available on T6SS core components and homologues.
| T6SS subunit | localization | PDB | homologue/localization | PDB |
|---|---|---|---|---|
| TssA | putative cytosolic protein | — | — | — |
| TssB | soluble protein, OM associated | — | bacteriophage sheath | 1FOH |
| TssC | soluble protein, OM associated | — | bacteriophage sheath | 1FOH |
| TssD/Hcp | soluble, forms hexameric rings, putative pilus | 1Y12, 3HE1, 3EAA | bacteriophage tail gp19 | 2K4Q, 2X8K, 2WZP, 2QWU |
| TssE | putative soluble protein | — | bacteriophage wedge gp25 | 2IA7 |
| TssF | putative soluble protein | — | — | — |
| TssG | putative soluble protein | — | — | — |
| TssH/ClpV | cytosolic protein, AAA+ ATPase | 3ZRI, 3ZRJ | Hsp100/Clp AAA+ ATPase | — |
| TssI/VgrG | cell puncturing device, forms trimers | 2P5Z | bacteriophage tail spike gp27-gp5 | 1K28 |
| TssJ/SciN | outer membrane lipoprotein | 3RX9, 4A1R | transthyretin | 1SN5 |
| TssK | putative cytosolic protein | — | — | — |
| TssL | inner membrane, 1 TM | 3U66 | T4bSS IcmH/DotU protein | — |
| TssM | inner membrane, 3 TMs | — | T4bSS IcmF protein | — |