Table 1.
Skeletal morphology and densitometry
| Parameter | Body mass covariate |
Main effect P < 0.05 |
Strain/surgery | |||
|---|---|---|---|---|---|---|
| HCR/sham (n = 6) |
HCR/OVX (n = 5) |
LCR/sham (n = 6) |
LCR/OVX (n = 6) |
|||
| Femoral diaphysis | ||||||
| Ct.A (mm2) | Sig. | Surgery | 5.1 ± 0.47 | 5.16 ± 0.58 | 5.71 ± 0.56 | 5.92 ± 0.49 |
| Ct.MA (mm2) | Sig. | – | 2.16 ± 0.55 | 2.30 ± 0.23 | 3.20 ± 0.29 | 3.33 ± 0.62 |
| Ct.Th (mm) | Sig. | – | 0.68 ± 0.04 | 0.69 ± 0.04 | 0.68 ± 0.05 | 0.69 ± 0.02 |
| Ixx (mm4) | Sig. | Surgery | 3.19 ± 0.64 | 3.11 ± 0.59* | 4.74 ± 0.76 | 5.33 ± 1.31 |
| Ct.TMD (mg cc−1) | – | Strain | 937 ± 142.7 | 979 ± 151.7 | 850.2 ± 12.6 | 851.1 ± 13.4 |
| Tibial diaphysis | ||||||
| Ct.A (mm2) | Sig. | – | 3.4 ± 0.26 | 3.58 ± 0.51 | 3.8 ± 0.34 | 4.05 ± 0.24 |
| Ct.MA (mm2) | Sig. | Strain | 0.81 ± 0.14# | 0.71 ± 0.12# | 1.19 ± 0.07 | 1.15 ± 0.16 |
| Ct.Th (mm) | Sig. | Strain | 0.65 ± 0.04# | 0.69 ± 0.07# | 0.64 ± 0.04 | 0.68 ± 0.04 |
| Ixx (mm4) | Sig. | – | 1.37 ± 0.16 | 1.45 ± 0.39 | 1.78 ± 0.30 | 2.04 ± 0.30 |
| Ct.TMD (mg cc−1) | – | – | 847.8 ± 13.7 | 863.4 ± 21.7 | 845.3 ± 6.9 | 849.5 ± 11.1 |
| Proximal tibial metaphysis | ||||||
| BVF | – | Surgery | 0.54 ± 0.16 | 0.39 ± 0.15 | 0.61 ± 0.13 | 0.42 ± 0.06* |
| Tb.Sp (mm) | Sig. | Strain | 0.09 ± 0.03# | 0.18 ± 0.14# | 0.08 ± 0.02 | 0.13 ± 0.02 |
| Tb.N (N mm−1) | – | – | 5.29 ± 0.81 | 4.53 ± 1.08 | 4.93 ± 0.53 | 4.59 ± 0.19 |
| Tb.TMD (mg cc−1) | – | Strain | 453 ± 20.6 | 445.9 ± 18.9 | 480.9 ± 25# | 463.5 ± 16.2 |
| Femoral neck | ||||||
| Ct.A (mm2) | – | – | 2.2 ± 0.34 | 2.17 ± 0.07 | 2.37 ± 0.15 | 2.34 ± 0.19 |
| Ct.Th (mm) | – | – | 0.37 ± 0.07 | 0.39 ± 0.03 | 0.4 ± 0.035 | 0.38 ± 0.064 |
| Ct.TMD (mg cc−1) | – | – | 718.3 ± 90.7 | 755.8 ± 87.9 | 693.8 ± 13.2 | 689.8 ± 33.9 |
| BVF | – | – | 0.41 ± 0.19 | 0.48 ± 0.11 | 0.46 ± 0.13 | 0.35 ± 0.12 |
| Tb.Sp (mm) | – | – | 0.14 ± 0.046 | 0.14 ± 0.034 | 0.11 ± 0.021 | 0.15 ± 0.036 |
| Tb.N (N mm−1) | – | – | 5.35 ± 0.46 | 5.55 ± 0.42 | 6.08 ± 0.34 | 5.36 ± 1.13 |
| Tb.TMD (mg cc−1) | – | – | 740.5 ± 65.6 | 766.2 ± 67.7 | 720.7 ± 17.3 | 711.2 ± 22.8 |
Sig. represents significance (P < 0.05) of animal body mass as a covariate.
*
Significantly different between surgery;
#
significantly different between strain