Table 1.
Sensitivity to rewarding and aversive effects of MA at the indicated dose |
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---|---|---|---|---|
Mice | Procedure | 0.5 mg/kg | 2 mg/kg | 4 mg/kg |
B6D2F2 | drug-free CPP | rewarding | neutral | neutral |
MALDR | drug-free CPP + | neutral | not tested | not tested |
MALDR-2 | drug-free CPP * | neutral | neutral | neutral |
MAHDR | drug-free CPP + | rewarding | not tested | not tested |
MAHDR-2 | drug-free CPP* | rewarding | rewarding | rewarding |
MALDR-2 | drug-present CPP* | aversive | aversive | aversive |
MAHDR-2 | drug-present CPP* | rewarding | neutral | neutral |
B6D2F2 | CPA | neutral | aversive | aversive |
MALDR-2 | CPA | neutral | aversive | aversive |
MAHDR-2 | CPA | neutral | neutral | aversive |
MALDR | CTA+ | not tested | aversive | not tested |
MALDR-2 | CTA | not tested | aversive | not tested |
MAHDR | CTA+ | not tested | neutral | not tested |
MAHDR-2 | CTA | not tested | neutral | neutral |
see Shabani et al., 2011.