Table 2.
Characteristics of brain metastasis (n = 41)
| Characteristic | No.(%) |
|---|---|
| Median age at diagnosis of HCC (range), years | 48.5(25-82) |
| Median interval between diagnosis of BM from HCC (range), months | 15(0-120) |
| Age at diagnosis of HCC (years) | |
| < 50 | 23(56.1%) |
| ≥ 50 | 18(43.9%) |
| Gender | |
| Female | 8(19.5%) |
| Male | 33(80.5%) |
| Site of extracranial metastases | |
| Lung | 31(75.6%) |
| Bone | 9(22%) |
| Adrenal gland | 4(9.8%) |
| other sites | 3(7.3%) |
| Radiological data | |
| CT | 22(53.7%) |
| MRI | 19(46.3%) |
| Location of brain lesions | |
| Supratentorial | 29(70.7%) |
| Infratentorial | 7(17.1%) |
| Combinations | 5(12.2%) |
| APF (ng/ml) | |
| < 400 | 15(36.6%) |
| ≥ 400 | 26(63.4%) |
| CEA (ng/ml) | |
| < 5 | 26(63.4%) |
| ≥ 5 | 5(12.2%) |
| Unkown | 10(24.4%) |
| CA199 (u/ml) | |
| < 35 | 22(53.7%) |
| ≥ 35 | 10(24.4%) |
| Unkown | 9(22%) |
| Symptom | |
| Headache | 17(41.5%) |
| Motor weakness | 14(34.1%) |
| Nausea | 12(29.3%) |
| Mental change | 6(14.6%) |
| Seizure | 4(9.8%) |
| Visual disturbance | 4(9.8%) |
| Cerebellar dysfunction | 3(7.3%) |
| Aphasia | 2(4.9%) |
| None | 1(2.4%) |
| Interval between diagnosis of HCC and BM (months) | |
| < 12 | 25(61%) |
| ≥ 12 | 16(39%) |
| Number of brain lesions | |
| 1 | 24(58.5%) |
| 2 | 4(9.8%) |
| ≥ 3 | 13(31.7%) |
| Brain hemorrhage | |
| Yes | 19(46.3%) |
| No | 22(53.7%) |
| KPS | |
| 90-100 | 6(14.6%) |
| 80-89 | 7(17.1%) |
| 70-79 | 12(29.3%) |
| 60-69 | 9(22%) |
| < 60 | 7(17.1%) |
| RPA class | |
| I | 1(2.4%) |
| II | 24(58.5%) |
| III | 16(39.0%) |