Table 5.
Univariate analysis of survival (n = 41)
| Patients | Mean survival (months) | Median survival (months) | p-Value (log-rank) | |
|---|---|---|---|---|
| Overall survival | 41 | 4.5 | 3 | |
| Characteristics | ||||
| Gender | 0.386 | |||
| Male | 33 | 4.7 | 3 | |
| Female | 8 | 3.6 | 2.5 | |
| Age (years) | ||||
| < 50 | 23 | 4.4 | 3 | 0.893 |
| ≥ 50 | 18 | 4.6 | 3.5 | |
| Primary tumor | 0.156 | |||
| Controlled | 16 | 5.8 | 3.5 | |
| Uncontrolled | 25 | 3.7 | 3 | |
| Etiology | ||||
| Hepatitis B | 30 | 4.1 | 3 | 0.308 |
| None | 11 | 5.6 | 3 | |
| Child-Pugh's classification | ||||
| A | 27 | 4.9 | 3.5 | 0.364 |
| B/C | 14 | 3.8 | 3 | |
| APF (ng/ml) | ||||
| < 400 | 15 | 3.4 | 2 | 0.218 |
| ≥ 400 | 26 | 5.1 | 3.5 | |
| CEA (ng/ml) | ||||
| < 5 | 26 | 4.8 | 3 | 0.725 |
| ≥ 5 | 5 | 3.9 | 3 | |
| CA199 (u/ml) | 0.455 | |||
| < 35 | 22 | 3.9 | 3 | |
| ≥ 35 | 10 | 5.6 | 3 | |
| Extracranial metastasis | ||||
| Yes | 33 | 5.2 | 3.5 | < 0.0001 |
| No | 8 | 1.4 | 1 | |
| Lung metastasis | ||||
| Yes | 31 | 5.4 | 4 | 0.001 |
| No | 10 | 1.7 | 1.7 | |
| Bone metastasis | ||||
| Yes | 9 | 5.8 | 4 | 0.272 |
| No | 32 | 4.1 | 2.5 | |
| Brain hemorrhage | ||||
| Yes | 19 | 4.1 | 1.5 | 0.495 |
| No | 22 | 4.9 | 3.5 | |
| Interval (months) | ||||
| < 12 | 16 | 3.5 | 3 | 0.272 |
| ≥ 12 | 25 | 5.1 | 3.5 | |
| Number of brain lesions | ||||
| Single | 24 | 4.2 | 3 | 0.572 |
| Multiple | 17 | 4.9 | 3.5 | |
| Location | ||||
| Supratentorial | 29 | 5 | 3 | 0.293 |
| Infratentorial or combinations | 12 | 3.4 | 1.5 | |
| Treatment | ||||
| Surgery or WBRT and/or SRS | 18 | 6.8 | 4.5 | 0.001 |
| Steroid only | 23 | 2.7 | 1.5 | |
| RPA class | ||||
| I or II | 25 | 6.4 | 6 | < 0.0001 |
| III | 16 | 1.6 | 1 |