Table 3.

Effect of 5-Aza-dC on expression of KDR and FLT4

	KDR		FLT4
	mRNA	induced by Aza	mRNA	induced by Aza
CMK	pos	-	pos	-
DOHH-2	neg	+	neg	++
EM-2	neg	(+)	neg	+++
HL-60	neg	+++	pos	-
L-82	neg	-	neg	+
SC-1	neg	++	neg	+

Induction of KDR and FLT4 by 5-Aza-dC (5 μM, 3 d) when compared to untreated control cells: - < 2.5-fold; (+) > 2.5-fold; + > 10-fold; ++ > 40-fold; +++ > 160-fold. Expression levels were determined by qRT-PCR. TBP expression was used as endogenous control, DMSO (0.05%) treated cells were used for normalization