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. 2012 Mar 8;8(3):e1002427. doi: 10.1371/journal.pcbi.1002427

Figure 2. Top and side views of the relative orientations between R1 and R2 in the 1∶2 complexes.

Figure 2

Cytokines are removed for clarity. (A) A coordinate system for defining the top and side views. The long axis of the C1 subdomain, identified with the principal axis corresponding to the largest moment of inertia, was chosen as the z axis (pointing upward). The x axis was chosen to be in the plane defined by the long axes of the C1 and N2 subdomains. This coordinate system is illustrated by the (GHR)2 complex, viewing into the y axis. Top (left) and side (right) views of (GHR)2, (EPOR)2, and (PRLR)2 are displayed in (B)–(D), with the cytokine names listed in the middle. In (B) and (D) side views, N2 is not displayed. In (C), C1 and C2 are not displayed in the top view, and N1 and N2 are not displayed in the side view. The coloring scheme in (A), (B), and (D) is the same as in Figure 1. In (C) the two EPORs in EMP1:(EPOR)2 and EMP3:(EPOR)2 are also displayed; receptors in complex with EPO, EMP1, and EMP33 are displayed in cyan, pink, and lime green, respectively (except that C1 in the side view is in orange). The values of γ and ϕ angles are also shown.