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. 2012 Mar 8;8(3):e1002422. doi: 10.1371/journal.pcbi.1002422

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Song et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Network nodes in different colors represent key network components in separate compartments (yellow: peritoneum, red: blood, and blue: lung). Edges represent network interactions compiled from literature (see text for details). Total 19 state variables including 8 observables. CLP, cecal ligation and puncture; B, bacteria; Nt, peritoneal neutrophil; Nr, resting blood neutrophil; Np, primed blood neutrophil; Na, activated blood neutrophil; PI, systemic pro-inflammatory response; AI, systemic anti-inflammatory response; Ns, neutrophil sequestered in lung capillaries; Nl, lung neutrophil; Lsel, L-selectin; HMGB1, High-mobility group protein B-1; CRT, creatinine; ALT, alanine aminotransferase; TNFa, tumor necrosis factor-; IL1b, interleukin-1 ; IL6, interleukin-6; IL10, interleukin-10.

Inline graphic — Network nodes in different colors represent key network components in separate compartments (yellow: peritoneum, red: blood, and blue: lung). Edges represent network interactions compiled from literature (see text for details). Total 19 state variables including 8 observables. CLP, cecal ligation and puncture; B, bacteria; Nt, peritoneal neutrophil; Nr, resting blood neutrophil; Np, primed blood neutrophil; Na, activated blood neutrophil; PI, systemic pro-inflammatory response; AI, systemic anti-inflammatory response; Ns, neutrophil sequestered in lung capillaries; Nl, lung neutrophil; Lsel, L-selectin; HMGB1, High-mobility group protein B-1; CRT, creatinine; ALT, alanine aminotransferase; TNFa, tumor necrosis factor-; IL1b, interleukin-1 ; IL6, interleukin-6; IL10, interleukin-10.