Table 1. Model parameters used for the baseline case.
ID | Name | Value () | Unit | Description |
1 | none | PI activation by bacteria | ||
2 | none | PI activation by damage | ||
3 | none | PI inhibition by AI | ||
4 | hr | PI decay | ||
5 | none | AI activation by PI | ||
6 | none | AI activation by | ||
7 | hr | AI decay | ||
8 | 3.22e-061.17e-06 | hr | basal neutrophil release from bone marrow reserve | |
9 | none | neutrophil release activation by bacteria | ||
10 | 3.15e-071.29e-07 | hr | maximum neutrophil release from bone marrow reserve in infection | |
11 | hr | resting blood neutrophil death | ||
12 | cells/ml | blood neutrophil priming by bacteria | ||
13 | hr | blood neutrophil priming | ||
14 | none | blood neutrophil activation by PI | ||
15 | hr | blood neutrophil activation | ||
16 | hr | primed neutrophil death | ||
17 | none | primed neutrophil activation by PI | ||
18 | hr | primed neutrophil activation | ||
19 | hr | neutrophil migration to tissue | ||
20 | hr | activated blood neutrophil death | ||
21 | none | activation of neutrophil sequestration by PI | ||
22 | hr | neutrophil sequestration | ||
23 | hr | sequestered neutrophil death | ||
24 | hr | primed neutrophil migration | ||
25 | cells/ml | activation of neutrophil migration to tissue | ||
26 | hr | inhibition of neutrophil migration to tissue | ||
27 | hr | tissue neutrophil death | ||
28 | none | sequestered neutrophil migration to lung | ||
29 | hr | lung neutrophil death | ||
30 | none | damage activation by sequestered neutrophil | ||
31 | none | damage activation by lung neutrophil | ||
32 | hr | damage resolution | ||
33 | 9.40e+073.04e+07 | numbers/ml/hr | Bacteria producing rate by CLP | |
34 | 6.61e-081.38e-08 | ml/neu/hr | Rate of bacteria removal by migrated neutrophils |
: activation/inhibition constant.
: time constant.