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. 2012 Mar 8;7(3):e33260. doi: 10.1371/journal.pone.0033260

Figure 6. Behavioral responses of avoiding (AV) and approaching (AP) mice in A/A Y-Maze and OF.

Figure 6

On the left side, the responses of AV animals treated with URB597 (URB) or vehicle (VHL) in A/A Y-Maze (A1, A2) and OF (C1–C4). AV+URB animals displayed enhancement of white choices and decrease of entry latencies mainly in entering the black arm, while they were more active in exploring the environment and contacting the object in the OF than AV+VHL animals. On the right side, the responses of AP animals treated with AM251 (AM) or vehicle (VHL) in A/A Y-Maze (B1, B2) and OF (D1–D4). AP+AM did not change the number of white choices, decreased entry latencies in the white arm in A/A Y-Maze, while they were less active in exploring the environment and contacting the object in the OF than AP+VHL animals. Abbreviations: W: white arm; B: black arm; S1: first session; S2: second session. Asterisks indicate the significance level of the post hoc comparisons between groups: * P<0.05; ** P<0.005; *** P<0.0005.