Table 1.
Baseline Characteristics, Anal Cancer Rates, and Rate Ratios by HIV Status, Men Who Have Sex With Men, and Sex, North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), Years 1996–2007
| HIV-Infected |
HIV-Uninfected |
||||
| MSM | Other Men | Women | Men | Women | |
| Baseline characteristics | |||||
| No. | 18 855a | 6492a | 8842 | 102 607 | 11 653 |
| Median age (IQR) | 38 (33–44) | 40 (35–46) | 36 (30–43) | 40 (34–47) | 37 (31–44) |
| Race/ethnicity | |||||
| Black | 3383 (18%) | 3360 (52%) | 4770 (54%) | 6153 (6%) | 1678 (14%) |
| White | 11 951 (63%) | 1773 (27%) | 2051 (23%) | 32 915 (32%) | 4306 (37%) |
| Otherb | 1946 (10%) | 732 (11%) | 1269 (14%) | 19 631 (19%) | 3201 (27%) |
| Unknown | 1575 (8%) | 627 (10%) | 752 (9%) | 43 908 (43%) | 2468 (21%) |
| HIV risk group | |||||
| MSM | 18 855 (100%) | 0 (0%) | 0 (0%) | … | … |
| IDU | 0 (0%) | 2225 (34%) | 1595 (18%) | … | … |
| Heterosexual | 0 (0%) | 3820 (59%) | 5433 (61%) | … | … |
| Other | 0 (0%) | 447 (7%) | 464 (5%) | … | … |
| Unknown | 0 (0%) | 0 (0%) | 1355 (15%) | … | … |
| Median year start of follow-up (IQR) | 2000 (1997–2004) | 2000 (1997–2003) | 2000 (1996–2003) | 1998 (1996–2003) | 1998 (1996–2003) |
| Median baseline CD4 cells/μL (IQR)c | 320 (140–505) | 225 (65–418) | 336 (155–538) | … | … |
| Anal cancer rates and rate ratios | |||||
| Cases | 122 | 14 | 15 | 13 | 0 |
| Person-years | 93 063 | 30 570 | 49 676 | 585 049 | 67 942 |
| Median years follow-up (IQR) | 4.0 (1.6–7.8) | 3.9 (1.6–7.2) | 5.3 (2.0–8.8) | 4.7 (2.0–10.0) | 5.0 (2.1–9.9) |
| Incidence rate per 100 000 person-years (95% CI) | 131 (109–157) | 46 (25–77) | 30 (17–50) | 2 (1–4) | 0 (0–5) |
| Rate ratio (95% CI) | 80.3 (42.7–151.1)d | 26.7 (11.5–61.7)d | Undefinede | Reference | Undefinede |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; IDU, injection drug use; IQR, interquartile range; MSM, men who have sex with men.
Excludes 2280 HIV-infected men with missing or unknown HIV risk group.
Other race/ethnicity category was predominantly Hispanic.
Closest CD4 test result within 1 year of start of follow-up; 0.8% had missing baseline CD4.
Rate ratios for HIV-infected MSM and other men compared with HIV-uninfected men from Poisson regression models adjusted for race/ethnicity, calendar era, age at entry into calendar era, and cohort.
Zero cases of anal cancer among the reference group of HIV-uninfected females.