Table 2.
Adjusted Anal Cancer Incidence Rate Ratios Between HIV-Infected Individuals Compared With HIV-Uninfected Individuals and With National US SEER Rates (Standardized Incidence Ratios), North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), Years 1996–2007
| Rate Ratio (95% CI)a,b |
Standardized Incidence Ratio (95% CI)c |
||||
| Calendar Era | MSM | Other Men | MSM | Other Men | Women |
| 1996–1999 | 60.8 (28.3–130.3) | 18.2 (3.9–85.0) | 73.9 (44.5–110.7) | 17.4 (2.1–48.6) | 0 (0–0)d |
| 2000–2003 | 100.8 (51.7–196.5) | 27.3 (9.1–81.8) | 115.6 (86.1–149.5) | 24.8 (8.1–50.8) | 41.5 (16.7–77.4) |
| 2004–2007 | 78.8 (40.8–152.1) | 31.9 (11.9–85.4) | 78.7 (58.2–102.2) | 20.3 (6.6–41.5) | 24.7 (9.1–48.0) |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; MSM, men who have sex with men.
Rate ratios for HIV-infected MSM and other men by calendar era compared with HIV-uninfected men (not stratified by era) from Poisson regression models adjusted for race/ethnicity (imputed for unknown), age at entry into calendar era, and cohort. The rate ratio was undefined for women because there were no cases in the reference group of HIV-uninfected women.
The P values for the rate ratios comparing 1996–1999 vs 2000–2003 and 2000–2003 vs 2004–2007 were P = .06 and P = .22, respectively, for MSM; and P = .63 and P = .79, respectively, for other men.
Age (<30, 30–39, 40–49, and ≥50) and sex and race/ethnicity (white, black, other) standardized incidence ratios computed using national US SEER rates from 1996 through 2005; individuals with missing race were dropped in the SIR analysis.
The SIR for women in 1996–1999 was 0 because the single female case diagnosed in 1996–1999 had missing race, and was therefore dropped in the SIR analysis.