Table 3.
Rate Ratios for Anal Cancer in HIV-Infected Individuals, North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), Years 1996–2007
| Univariate Modela |
Multivariable Modela |
|||||
| Variable | RR | (95% CI) | P Value | RR | (95% CI) | P Value |
| MSM status/sex | ||||||
| HIV-infected MSM | 2.8 | 1.6–4.9 | <.001 | 3.3 | 1.8–6.0 | <.001 |
| HIV-infected other men | 1.0 | Ref | … | 1.0 | Ref | … |
| HIV-infected women | 0.7 | 0.3–1.4 | .26 | 1.0 | 0.5–2.2 | .97 |
| Calendar era | ||||||
| 1996–1999 | 0.6 | 0.4–0.9 | .013 | 0.5 | 0.3–0.9 | .011 |
| 2000–2003 | 1 | Ref | … | 1.0 | Ref | … |
| 2004–2007 | 0.8 | 0.6–1.2 | .35 | 0.9 | 0.6–1.2 | .36 |
| Race/ethnicity | ||||||
| Black | 0.7 | 0.5–1.0 | .087 | 1.2 | 0.8–1.7 | .46 |
| White | 1.0 | Ref | … | 1.0 | Ref | … |
| Otherb | 0.3 | 0.1–0.6 | .002 | 0.3 | 0.1–0.7 | .004 |
| Age (per 10 years) | 1.4 | 1.2–1.7 | <.001 | 1.3 | 1.1–1.5 | .009 |
| Baseline CD4, cells/μL | ||||||
| <200 | 1.0 | Ref | … | 1.0 | Ref | … |
| 200–349 | 0.5 | 0.3–0.8 | .002 | 0.5 | 0.4–0.8 | .003 |
| 350–499 | 0.5 | 0.3–0.7 | .001 | 0.5 | 0.3–0.7 | <.001 |
| ≥500 | 0.2 | 0.1–0.3 | <.001 | 0.2 | 0.1–0.3 | <.001 |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; MSM, men who have sex with men; Ref, reference; RR, rate ratio.
a
RRs obtained from Poisson regression models. Multivariable model adjusted for all variables in table and also for cohort.
b
Other race/ethnicity category was predominantly Hispanic.