Skip to main content
. Author manuscript; available in PMC: 2012 Sep 8.
Published in final edited form as: Nature. 2012 Feb 19;483(7388):209–212. doi: 10.1038/nature10801

Figure 3. dpiezo mediates mechanically-activated currents in ppk-positive neurons.

Figure 3

(a) Representative currents elicited by negative pipette pressure (0 to −60 mmHg, Δ 10 mmHg) in cell-attached configuration at −80mV in wild type (left) and dpiezo−/− (right). (b) Average peak current-to pressure relationship of stretch activated currents in wild type (n = 12 cells) and dpiezo−/− (n =13 cells). Data points are mean ± SEM. fitted with a Boltzmann equation. ** P < 0.01, *** P < 0.001, Mann-Whitney test.