Table 5.

Uni/ Multivariate analysis

Univariate analysis (Survival)							Multivariate analysis (Cox Proportional Hazards Model)**
Variable	Category	N	Median Survival in months (Range)	Hazard Ratio (CI)	p value	Adjusted p* value	CI	P value
Gender	Female	18	37.9 (3.5 - 59.2)	0.66 (0.31- 1.42)	0.281
	Male	22	26.4 (1.1 - 72.9)	1
Age	<65	27	39.1 (1.1 – 72.9)	0.48 (0.20 – 1.15)	0.058		0.41 (0.16 – 1.05)	0.066
	≥65	13	22.4 (1.7 - 59.2)	1
ECOG Performance score	0	30	56.2 (3.5 - 72.9)	0.13 (0.03 – 0.55)	<0.0001	0.008	0.04 (0.009 – 0.19)	0.0001
	>0	10	6.9 (1.1 - 10.6)	1
Liver replacement by tumor %	≤ 25%	32	56.1 (1.1 - 72.9)	0.29 (0.09 – 0.98)	0.0019	0.015	0.63 (0.20 – 1.91)	0.41
	> 25%	8	15.4 (1.7 – 34.4)	1
Lesions >4	No	3	37.9 (4 - 37.9)	0.79 (0.16 – 3.91)	0.755
	Yes	37	29.9 (1.1 - 72.9)	1
Extrahepatic disease	No	26	39.1 (1.1 - 72.9)	0.53 (0.22 - 1.29)	0.108		0.73 (0.25 – (2.06)	0.55
	Yes	14	22.1 (3.5 - 56.2)	1
Albumin	≥3.5 g/dL	15	58.9 (1.7 – 72.9)	0.39 (0.18 – 0.84)	0.017	0.08	0.45 (0.15 – 1.34)	0.15
	<3.5 g/dL	25	22.0 (1.1 – 56.1)	1
Bilirubin	≤1.2 mg/dL	38	37.9 (1.1 – 72.9)	0.14 (0.004 – 5.02)	0.002	0.016	0.08 (0.01-0.74)	0.02
	>1.2 mg/dL	2	5.2 (1.7 – 8.7)	1

^*Adjusted for multiple comparison (correction factor=8)

^**Factors were included in multivariate analysis if p <.25 in univariate analysis (unadjusted for multiple comparisons)

Abbreviations: ECOG: Eastern Cooperative Oncology Group