Table 6.
Study | No. of patients | Device/Method used | Toxicity | Radiologic Response | Survival times & rates |
---|---|---|---|---|---|
Rhee23 | 42 | Yttrium-90 (glass) | Grade III/IV (14%) | 54% | Median:22 months |
Yttrium-90 (resin) | 50% | Median: 28 months | |||
Kennedy2 | 148 | Yttrium-90 | 33% (grade III), fatigue (6.5%) | 63% | Median: 70 months |
King25 | 58 | Yttrium-90 | Radiation gastritis (2 patients), duodenal ulcer (1 patient), | 39% | Median : 36 months 1,2,3 year survival: 86%, 58%, and 47% |
Saxena24 | 48 | Yttrium-90 | 0.5% (grade III) 1 patient (biliary obstruction) | 54% | Median: 35 months 1,2,3 year survival: 87%, 62%, and 42% |
Dong8 | 123 | TACE | Abdominal pain (44%), diarrhea (30%), weight loss (22%) | 62% | Mean: 3.3 years 3, 5 and 10 year survival : 59%, 36% and 20% |
de Baere26 | 20 | TACE with doxorubicin eluting beads | Nausea (61%), fever (36%) | 80% | - |
Vogl27 | 48 | TACE with mitomycin C | Nausea and vomiting (27.8%), abdominal pain (11.1%) | 11.1% | Median:38.6 7 months 5 year: 11.11% |
TACE with mitomycin C + gemcitabine | Nausea and vomiting (16.7%), abdominal pain (10%) | 23.33% | Median: 57.1 5 year: 46.67% |
||
Loewe29 | 23 | Bland embolization | - | 73% | Median: 69 months 1 and 5 year survival: 95.7% and 65.4% |
Eriksson30 | 41 | Bland Embolization | Postembolization syndrome (all), nausea (33%), fever (7 patients), median hospitalization: 12 days | 50% | Median: 80 months 5 year: 60% |
Current Study | 40 | Yttrium-90 | Fatigue (63%, all grades), nausea/vomiting (40%, all grades), grade III, IV (bilirubin:8%; albumin:2%; lymphocute:38%) | WHO:64%; EASL: 63.9% | Median: 34.4 months 1,2, 3 year survival: 72.5%, 62.5%, 45% |