Table 1. Glutathione, lipid peroxides , Egr-1 content, and triglycerides in livers of mice gavaged with varying doses of ethanol.
Ethanol dose (g/kg body wt) |
0 | 2 | 4 | 6 |
---|---|---|---|---|
Glutathione (GSH) (nmoles/ mg protein) |
15 ± 2a | 15 ± 4a | 18 ± 1a | 8 ± 2b |
Lipid peroxides (nmoles MDA/g liver) |
321 ± 70a | 386 ± 72a | 655 ± 60b | 1359 ± 150c |
Egr-1/actin ratio | 0.44 ± 0.1a | 0.39 ± 0.03a | 0.77 ± 0.12 ab | 0.86 ± 0.07b |
Triglycerides (mg/g liver) |
12 ± 1a | 14 ± 1.5a | 36 ± 8b | 38 ± 6b |
Note: Parameters were measured 12 hours after gavaging C57Bl/6 mice with the indicated doses of ethanol. Data are mean values (± SEM) from 4 to 11 mice per ethanol dose. Data with superscripts with different letters are significantly different from each other. Data with superscripts with the same letter are not significantly different from each other.