Table 2.

Patterns of CD4 and CD8 T Cell Distribution in Different Biopsies Compared to Assessment of TCR β-Chain Sequence Diversity

				Periglomerular							Tubules						β-Chain Sequence Diversity
		CD8	CD4	CD8	CD4	CD8	CD4	CD8/CD4	CD8	CD4	CD8	CD4	CD8	CD4	CD8	CD4	Simpson Diversity Index
Case No.	Yr Bx	Intra-Glomerular		Aggregate		Focal Cap		Mixed Cap	Adherent		Intertubular interstitium		Tubulitis		Adherent basal Tubule		Peri-glomerular interstitium	Peri-tubular interstitium
1	2007	0	0	0	3	0	2	0	1	2	0.5	4	1	0	0	0
2	2007	0	0	0	3	0	1	1	0	2	0	1	0	0	0	0
2	2008	0	0	0	3	2	4	3	1	4	0.5	3	4	0	1	0
3	2004	0	0	0	0	0	0	0	0	0	1	0.5	0	0	1	0
3	2007	2	0	0	4	2	2	0	2	1	2	3	3	0.5	2	0.5
4	2006	0	0	0	3	0	0	0	0.5	0	2	1	1	0	1	0	0	0
5	2005	0	0	0	3	1	0	0	2	0	3	1	2	0	0	0	0.86
6	2006	2	0	0	3	2	0	0	1	0	2	2	3	0	2	0	0	0.75
7	2003	0.5	0	0	2	1	0.5	0	3	0	3	2	2	0	2	0
7	2005	0	0	0	2	2	0	2	2	1	2	0.5	3	0	1	0
8	2003	0	0	0	2	2	1	0	2	0.5	2	0.5	0	0	0	0	0.75	0.86
9	2006	0.5	0	0	2	0	0	0	2	0	1	2	3	0.5	1	0	0.53	0.74
10	2006	3	0	0	1	0	0	0	3	0	3	3	2	0	2	0
11	2007	1	0	0	0	2	2	4	2	4	3	4	4	1	3	1		0.59
12	2005	1	0	0	0	2	3	3	1	0	1.5	1.5	1	0	1	0		0.56
13	2004	1	0	0	2	3	3	2	2	2	4	0	1	0	2	0
13	2005	0	0	0	0	0	0	3	1	0	3	0.5	4	0.5	3	0		0.31
13	2008	0	0	0	0	0	2	2	1	0	2	2	4	0	0	0	0.69	0.61
14	2007	2	0	0	0	2	0	3	3	0.5	4	1	4	1	3	0	0	0.64
15	2006	0	0	0	0	0	0	0	2	1	1	1	1	0	1	0	0.73	0.82
15	2009	0	0	0	0	0	0	4	2	3	4	3	4	1	3	1
16	2002	0	0	0	0	2	0	0	2	0	0.5	0	0	0	0	0		0
17	2006	2	0	0	0	2	1	0	3	1	1	0.5	2	1	0	0
17	2007	3	0	0	0	4	0.5	0.5	3	0	3	1	3	0	3	0	0.77

Semiquantitative grading (0-4+) of the number and extent of infiltrating T cells in each pattern of distribution, 0=absent, 0.5=trace, 1=mild, 2=moderate, 3=severe and focal, 4 severe and diffuse; The Simpson Diversity Index summarizes the number and extent of clonal expansions demonstrated by sequencing, 0=a single clone, 1=a polyclonal repertoire.