Table 1.

Observed and expected numbers of BRCA1 and BRCA2 mutations in a subset of individuals (n = 263)

Observed (O)	Expected (E)	O/E (95% CI)	ROC area (95% CI)
BRCA1			BRCA1 versus non-BRCA1
47 (2 P)	33	1.43 (1.05–1.90)*	0.86 (0.79–0.91)
BRCA2			BRCA2 versus non-BRCA2
13 (1 P)	21	0.63 (0.34–1.08)	0.69 (0.58–0.78)
BRCA(1 or 2)			BRCA1 or BRCA2 versus non-carriers
60 (3 P)	54	1.12 (0.86–1.44)	0.83 (0.76–0.88)

Discrimination between carriers and non-carriers of mutations in BRCA1 and/or BRCA2 as measured by area under the ROC curve

P, analyses of paraffin embedded tissue. * Significant deviation from 1