Figure 5.
Sodium current in male ventricular cardiomyocytes at 3 weeks showing altered sodium channel function by the DN allele. A, Representative current traces in H/H, DN/H, and DN/DN cells. See Table 3 for summary results. B, Current voltage relationships. C, Late sodium current at −30 mV. Late current amplitude was normalized to peak current amplitude. D, Voltage dependence of activation and inactivation. E and F, Inactivation time constant (τ) at −30 mV. *P<0.001 versus H/H. †P<0.001 versus DN/H. N indicates the number of cardiomyocytes from 3 mice.