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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Nature. 2012 Feb 22;483(7387):96–99. doi: 10.1038/nature10852

Figure 1. Klf15 expression, ECG QTc interval and expression of repolarizing ion channels exhibit endogenous circadian rhythm.

Figure 1

(a) Klf15 expression exhibits endogenous circadian variation in WT hearts from mice in constant darkness (DD) (n=4 per time point) (CT – Circadian Time). (b) BMAL1 ChIP on Klf15 promoter illustrating rhythmic variation in binding of BMAL1 to the Klf15 promoter in WT hearts (n=3 per group). (c) ECG QTc interval in conscious mice exhibits endogenous circadian variation in constant darkness (n=4). (d) Representative ECG’s from conscious mice after 36 hours in constant darkness at CT 0 and CT 12 (CT - Circadian Time). (e, f) Endogenous circadian variation in transcripts for Kv4.2 and KChIP2 in WT hearts measured every four hours after 36 hours in constant darkness (n=4 per time point). Data presented as mean ± SEM.