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. 2012 Jan 13;31(5):1231–1240. doi: 10.1038/emboj.2011.489

Figure 1.

Figure 1

Effect of MVs on neurotransmission in hippocampal cultures. (A) Representative traces of mEPSCs from control neurons and neurons exposed to MVs. (B) Changes of mEPSC frequency evoked by MVs in a microglia-to-neuron ratio of 1:1 (MVs concentration=1.2 μg/ml), 2:1 (MVs concentration=2.38 μg/ml), and 4:1 (MVs concentration=4.76 μg/ml); N=3; one-way ANOVA followed by Dunn's method, P<0.001. (C) Cumulative distribution of mEPSC amplitude from control and MV-treated neurons; n=15 controls; n=12 MV-treated neurons; t-test followed by Mann–Whitney, P=0.054. (D, E) Rise time (D), t-test followed by Mann–Whitney rank-sum test, P=0.071 and decay time (E), n=10 controls; n=15 MV-treated neurons; test followed by Mann–Whitney, P=0.006 of mEPSCs from control and MV-treated neurons. (F, G) Examples of stimulus-evoked EPSCs in control and MV-treated paired mouse neurons (F) and corresponding mean amplitude (G); t-test P=0.001, N=3, 11 versus 10 pairs, respectively. (H, I) Representative traces of short-term plasticity in paired mouse neurons (H) and quantitative analysis of paired-pulse ratio (I); n=10 pairs per conditions, N=3, t-test followed by Mann–Whitney rank-sum test, P=<0.001. (J) Representative sucrose-evoked responses from control and MV-treated neurons. (K, L) Mean amplitude (nA) and total charge (pC) of sucrose-evoked responses; N=4, n=16 Ctr; n=24 MV-treated cells; current (nA), t-test followed by Mann–Whitney rank-sum test, P=0.025; charge transferred (nC), P=0.042.