Table 2.
Top significant haplotypes identified from the discovery cohort
| Hap | CHR | P-value | Gene |
|---|---|---|---|
| rs5743289|rs2076756 | 16 | 2.35E−17 | NOD2 |
| rs2076756|rs5743291 | 16 | 2.70E−17 | NOD2 |
| rs10521209|rs5743289 | 16 | 1.51E−16 | NOD2 |
| rs2066843|rs10521209 | 16 | 2.40E−15 | NOD2 |
| rs11647841|rs2066843 | 16 | 5.24E−15 | NOD2 |
| rs8057341|rs11647841 | 16 | 4.56E−14 | NOD2 |
| rs7194886|rs8057341 | 16 | 9.87E−14 | |
| rs9302752|rs7194886 | 16 | 5.28E−13 | |
| rs790631|rs7517847 | 1 | 1.47E−10 | IL23R |
| rs1004819|rs790631 | 1 | 1.78E−10 | IL23R |
| rs7143973|rs9285572 | 14 | 1.38E−09 | |
| rs1343151|rs10889675 | 1 | 1.78E−09 | IL23R |
| rs7530511|rs10489629 | 1 | 4.75E−09 | IL23R |
| rs10889675|rs10889677 | 1 | 3.68E−08 | IL23R |
| rs10489629|rs2201841 | 1 | 4.51E−08 | IL23R |
| rs2241880|rs3792106 | 2 | 7.81E−08 | ATG16L1 |
| rs2289476|rs2241880 | 2 | 7.81E−08 | ATG16L1 |
| rs2201841|rs11804284 | 1 | 7.94E−08 | IL23R |
| rs3818562|rs4970779 | 1 | 1.08E−07 | EPS8L3 |
| rs2302759|rs4785452 | 16 | 1.13E−07 | CYLD |