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. Author manuscript; available in PMC: 2012 Mar 9.
Published in final edited form as: J Immunol. 2009 Nov 30;184(1):277–286. doi: 10.4049/jimmunol.0902373

FIGURE 2.

FIGURE 2

CD4+ T cell help does not influence the size of the gB-CD8+ T cell effector or memory population. B6 mice that received HSV-1 corneal infections were continuously depleted of CD4+ T cells beginning 2 d before (A) or 8 d after (B) infection. At the indicated dpi, TGs were excised and gB-CD8s were quantified by simultaneous staining with anti-CD8α mAb and tetramers containing the immunodominant HSV-1 gB498–505 epitope (gB498–505 H2-Kb). A, Mean ± SEM of the absolute number of gB-CD8s per TG in nondepleted (helped) and continuously CD4-depleted starting −2 dpi (nonhelped) mice. B, Mean ± SEM of the absolute number of gB-CD8s per TG in nondepleted (helped) and continuously CD4-depleted starting +8 dpi (CD4-depleted > 8 dpi) mice. *p < 0.05; ***p < 0.001; n = 10–15 mice per group.