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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Nat Med. 2012 Feb 26;18(3):436–440. doi: 10.1038/nm.2610

Figure 4. RUNX1 mutations in T-ALL.

Figure 4

(a) Schematic representation of RUNX1 mutations identified in T-ALL. Runt: RUNX1 DNA binding domain; AD: activation domain; ID: inhibitory domain (b) Representative DNA sequencing chromatograms of paired diagnostic and remission genomic DNA T-ALL samples showing somatically acquired mutations in the RUNX1 gene. (c) Molecular surface rendition depicting the interaction between the RUNX1 runt domain (grey), DNA and CBFB (green) complex. RUNX1 mutations present in T-ALL and AML are indicated in orange. RUNX1 mutations found in AML are depicted in yellow. (d) Effects of RUNX1 T-ALL mutant alleles in the activity of a CSF promoter reporter construct. The size of the nodes in the star diagrams is proportional to the significance P value as indicated in the scale at the bottom.