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. Author manuscript; available in PMC: 2013 Mar 7.
Published in final edited form as: J Med Chem. 2012 Feb 15;55(5):2311–2323. doi: 10.1021/jm201547v

Figure 1.

Figure 1

Roles of CYP17A1 and AKR1C3 in androgen biosynthesis and their inhibition by abiraterone acetate and NSAIDs. (HSD3B2 is Type 2, 3β hydroxysteroid dehydrogenase and SRD5A is 5α-reductase)