Table 1.

Pooled logistic regression of IL12RB2 genetic variants in the GWAS cohort (2309 SSc patients and 5161 controls)

SNP	Chr: 1 position (bp)	Minor allele	Plog	OR	PGC	P-value: add to rs3790567	OR and rs3790567	P-value rs3790567 add to SNP	OR rs3790567 and to SNP	r2 with rs3790567
rs924080	67,532,728	G	2.93 × 10−2	1.08	3.91 × 10−2	0.12	1.06	2.16 × 10−5	1.19	0.02
rs12131065	67,541,594	A	0.16	0.94	0.18	0.20	0.95	7.72 × 10−6	1.19	0.001
rs3790558	67,549,609	C	0.31	1.04	0.34	0.19	0.95	4.74 × 10−6	1.23	0.23
rs10489627	67,552,264	G	4.88 × 10−2	1.08	0.06	0.83	0.99	4.98 × 10−5	1.20	0.23
rs2066445	67,554,563	A	0.09	0.93	0.11	0.11	0.93	7.62 × 10−6	1.20	0.0005
rs3790567	67,594,965	A	6.36 × 10−6	1.20	1.92 × 10−5	NA	NA	NA	NA	NA
rs3828069	67,612,161	G	4.24 × 10−2	0.91	0.05	0.44	0.96	4.28 × 10−5	1.19	0.08
rs4297265	67,624,923	G	1.71 × 10−2	1.09	2.41 × 10−2	0.39	0.96	9.86 × 10−5	1.23	0.44
rs2270614	67,628,609	A	1.66 × 10−2	1.09	2.34 × 10−2	0.41	0.96	1.04 × 10−4	1.23	0.44
rs7555183	67,633,215	A	0.24	1.05	0.27	0.92	1.00	1.31 × 10−5	1.20	0.08

Chr, chromosome; P_log, logistic regression P-value; OR, odds ratio; P_GC, GC corrected P-value. Last columns, single locus test P-value when SNP added to rs3790567, single locus test OR when SNP added to rs3790567, single locus test P-value when rs3790567 added to SNP in logistic regression analyses, single locus test OR when rs3790567 added to SNP in logistic regression analyses and pairwise r² of SNP with rs3790567. NA, not applicable.