Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Alignment of divergent motifs in the AT and KR domains of the herboxidiene PKS. (A) Methylmalonyl-CoA-specific and malonyl-CoA-specific ATs. The underlined residues are associated with malonyl-CoA and methylmalonyl-CoA specificity. (B) Alignment of the conserved motifs in KRs. KR1 belongs to A1-type KRs (1, no LDD; 2, W; 3, no H). KR3, -4, -5, -6, -7, and -8 fall into the B1 type (1, LDD; 4, no P). The conserved motifs of KR2 are obscure, and the type of this domain remains unclear.
