Table I.
Distribution of the CBS 844ins68 polymorphism between HNSCC patients and controls
| CBS 844ins68 polymorphism | Patients n (%) | Controls n (%) | OR (95% IC) | P |
|---|---|---|---|---|
| Genotypes | n = 322 | n = 531 | ||
| NN (Non-insertion) | 258 (80) | 443 (83.4) | 1.00 (ref) | |
| IN (Heterozygous) | 56 (17.5) | 78 (14.6) | 1.15 (0.74-1.79) | 0.53 |
| II (Polymorphic) | 08 (2.5) | 10 (2.0) | ||
| Alleles | ||||
| Non insertion (N) 68bp | 315 (83.1) | 521 (82.8) | 1.00 (ref) | |
| Insertion 68 bp(I) | 64 (16.9) | 88 (17.2) | 1.20 (0.85-1.71) | 0.30 |
NN – 68 bp non-insertion, IN – heterozygous – CBS 844ins68, II – CBS 844ins68 polymorphic. Adjusted for age, gender, tobacco and alcohol habits. The genotypes was calculated for polymorphic homozygous individuals or carrying risk allele heterozygous vs. wild-type homozygous. p < 0.05 was considered significant. There was no difference statistically significant (multiple logistic regression)