Table 3b.
Treatment Characteristics of a Matched Sub-Cohort of NSCLC Surgical Patients According to HIV-infected and HIV-Unspecified Status. (N=88)
| HIV-Infected (n=22) |
HIV-Unspecified† (n=66) |
||||
|---|---|---|---|---|---|
| Characteristics | # | % | # | % | p value* |
| ASA | 0.101 | ||||
| 2 | 0 | 0.0 | 10 | 15.2 | |
| 3 | 20 | 90.9 | 53 | 80.3 | |
| 4 | 2 | 9.1 | 3 | 4.5 | |
| Median time from diagnosis to surgery, days & IQR | 72 | 36 - 108 | 40 | 15 – 91 | 0.020 |
| Median length of hospital stay, days and IQR | 9 | 6 - 12 | 5 | 4 – 7 | 0.025 |
| Neoadjuvant Therapy | 0.503 | ||||
| None | 54 | 81.8 | 20 | 90.9 | |
| Received | 12 | 18.2 | 2 | 9.1 | |
| Adjuvant Therapy | 0.367 | ||||
| None | 41 | 62.1 | 16 | 72.7 | |
| Received | 25 | 37.9 | 6 | 27.2 | |
| Pulmonary Function | |||||
| Mean FVC % predicted, ± S.D | 87.8 | 17.3 | 82.8 | 18.3 | 0.314 |
| Mean FEV1 % predicted, ± S.D | 80.4 | 24.9 | 72.9 | 19.9 | 0.262 |
| Mean DLCO % predicted, ± S.D | 69.1 | 20.6 | 86.1 | 25.2 | 0.025 |
| Postoperative Complications§ | |||||
| Pulmonary | 13 | 59.1 | 12 | 18.2 | 0.001 |
| Cardiac | 0 | 0.0 | 3 | 4.5 | 0.570 |
| Infectious | 8 | 36.4 | 3 | 4.5 | <0.001 |
| Neurologic | 0 | 0.0 | 2 | 3.0 | 0.899 |
| Bleeding | 4 | 18.2 | 1 | 1.5 | 0.013 |
| Other Complications | 6 | 27.3 | 2 | 3.0 | 0.003 |
| At least two postoperative complications | <0.001 | ||||
| <2 | 12 | 54.5 | 60 | 90.9 | |
| ≥2 | 10 | 45.5 | 6 | 9.1 | |
| Mean number of days until first complication, days and ± S.D | 3 | 2.4 | 3 | 1.9 | 0.985 |
| 30-Day Mortality | 0 | 0.0 | 1 | 1.5 | 0.994 |
| Cause of Death | 0.361 | ||||
| Lung cancer-related | 11 | 61.1 | 27 | 60.0 | |
| AIDS-related | 1 | 5.6 | 0 | 0.0 | |
| Other Causes‡ | 4 | 22.2 | 15 | 33.3 | |
| Cause Unknown | 2 | 11.1 | 3 | 6.7 | |
HIV-unspecified patients were matched on age, sex, race, stage, NSCLC histology, surgery date, and surgical procedure.
χ2 test for homogeneity or Fisher's exact test for binary and categorical variables and Mann-Whitney U test or Student's t-test for continuous variables.
Postoperative complications include, Pulmonary: air leak (13), atelectasis (6), pneumothroax (7), pleural effusion (7), pulmonary embolus (3), ARDS (1), respiratory failure (1), hypoxia (1); Cardiac: dysrhythmia (2),MI(1); Infectious: pneumonia (4), fever (4), wound infection (4), bronchiopleural fistula (1), chest infection (1); Neurologic: mental status (2); Bleeding: thoracic wall hemotoma (1), tracheostomy bleeding (1), persistent hemoptysis (1), chest hemorrhage (1); Other complications: renal failure (2), reintubation (2), blood clot (1), ileus (1), uncontrolled pain (1), secondary cancer diagnosis (1). Note- some patients had multiple postoperative complications within a broader categories listed in the table above.
Other causes of death include, HIV-infected: bleeding from tracheostomy (oropharyngeal cancer) (1), CHF/atherosclerotic CVD(1), respiratory failure septic shock ascending cholangitis hepatic artery injury PEA arrest(1), multisystem organ failure following cardiac surgery (1). HIV-unspecified: CVD/ MI (5), pulmonary arrest (2), pneumonia (1), diabetic complication (1), arteriovenous malformation complications (1), pyriform sinus cancer (1), multiple myeloma (1), esophageal cancer (1), breast cancer (1), head and neck cancer (1).
ASA, American Society of Anesthesiology Classification morbidity index; DLCO, diffusion capacity of the lung for carbon monoxide; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; IQR, interquartile range; S.D., standard deviation.