Figure 8.

Celastrol nanoparticles inhibit the expression of angiogenic factor proteins in the cornea. Corneas were harvested on day 6 after surgery and the concentration of (A) vascular endothelial growth factor, (B) matrix metalloproteinase 9, and (C) monocyte chemoattractant protein 1 in the corneal tissue lysates were assessed by enzyme-linked immunosorbent assay.

Notes: The data are presented as mean ± standard deviation of three independent experiments. Statistical significance is based on the difference when compared with the control; *P < 0.001.

Abbreviations: CNPs, celastrol nanoparticles; MCP-1, monocyte chemoattractant protein 1; MMP-9, matrix metalloproteinase 9; VEGF, vascular endothelial growth factor.