Table 2.
BAL fluid counts in mice.
| Control | NanoTiO2 | Indoor-R | Indoor-NanoTiO2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 day | 18 μg | 54 μg | 162 μg | 54 μg | 162 μg | 486 μg | 54 μg | 162 μg | 486 μg | ||
| Neutrophils (x103) | 7.7 ± 1.7 | 4.9 ± 1.5 | 56.8 ± 7.2*** | 189.9 ± 29.1*** | 14.2 ± 3.5 | 61.7 ± 17.8** | 176.5 ± 18.8*** | 19.7 ± 3.5 | 58.2 ± 10.5** | 170.4 ± 25.3*** | |
| Macrophages (x103) | 53.2 ± 2.5 | 64.1 ± 6.9 | 56.4 ± 5.8 | 41.4 ± 6.2 | 61.1 ± 7.7 | 69.5 ± 4.1 | 78.9 ± 13.1 | 73.0 ± 7.1 | 68.8 ± 6.6 | 51.4 ± 7.2 | |
| Eosinophils (x103) | 0.3 ± 0.4 | 0.3 ± 0.2 | 1.3 ± 0.7 | 2.1 ± 0.6 | 0.2 ± 0.1 | 2.0 ± 1.0 | 20.5 ± 3.1*** | 0.2 ± 0.2 | 1.3 ± 0.5 | 10.1 ± 5.4*** | |
| Lymphocytes (x103) | 1.6 ± 0.2 | 1.2 ± 0.5 | 1.0 ± 0.3 | 2.4 ± 1.0 | 0.7 ± 0.2 | 2.1 ± 0.8 | 3.4 ± 1.4 | 0.9 ± 0.2 | 2.2 ± 0.8 | 2.7 ± 1.0 | |
| Total BAL cells (x103) | 74.0 ± 3.6 | 77.6 ± 8.8 | 123 ± 12.8** | 246.5 ± 31.1*** | 85.4 ± 8.2 | 146.4 ± 22.1*** | 298.8 ± 25.5*** | 106.3 ± 9.5 | 139.2 ± 14.2*** | 256.3 ± 29.5*** | |
| 3days | |||||||||||
| Neutrophils (x103) | 3.0 ± 2.3 | 0.9 ± 0.5 | 6.5 ± 1.0** | 78.1 ± 10.5*** | 2.6 ± 1.9 | 4.4 ± 1.6 | 17.4 ± 2.7*** | 1.5 ± 0.5 | 3.7 ± 0.9 | 21.4 ± 5.3*** | |
| Macrophages (x103) | 56.4 ± 4.2 | 58.9 ± 8.5 | 57.3 ± 6.9 | 84.2 ± 0.8 | 56.5 ± 6.2 | 69.7 ± 6.3 | 128.9 ± 8.2*** | 69.2 ± 7.9 | 85.6 ± 5.6* | 106.6 ± 6.8*** | |
| Eosinophils (x103) | 0.4 ± 0.6 | 0.5 ± 0.2 | 0.9 ± 0.3 | 9.7 ± 6.5 | 4.8 ± 0.4 | 8.4 ± 2.2*** | 45.0 ± 8.3*** | 0.9 ± 0.3 | 7.9 ± 3.8*** | 19.0 ± 7.5*** | |
| Lymphocytes (x103) | 0.9 ± 0.2 | 0.8 ± 0.3 | 0.8 ± 0.2 | 4.6 ± 1.8 | 1.5 ± 0.7 | 6.7 ± 1.6*** | 14.1 ± 4.4*** | 1.3 ± 0.3 | 2.9 ± 1.3 | 8.5 ± 3.4* | |
| Total BAL cells (x103) | 69.1 ± 6.4 | 66.9 ± 8.6 | 71.8 ± 8.3 | 185.3 ± 14.0*** | 69.3 ± 6.6 | 99.4 ± 7.6 | 221.4 ± 17.2*** | 81.0 ± 8.2 | 109.3 ± 4.8*** | 174.9 ± 19.4*** | |
| 28 days | |||||||||||
| Neutrophils (x103) | 1.2 ± 0.2 | 1.1 ± 0.3 | 2.8 ± 0.6 | 14.7 ± 2.7*** | 0.6 ± 0.4 | 1.2 ± 0.4 | 1.4 ± 0.2 | 1.1 ± 0.4 | 1.8 ± 0.9 | 6.6 ± 2.0 | |
| Macrophages (x103) | 82.4 ± 5.7 | 79.5 ± 5.4 | 71.8 ± 10.7 | 106.2 ± 14.6 | 54.1 ± 3.6 | 64.0 ± 3.6 | 91.2 ± 13.3 | 94.6 ± 23.5 | 92.8 ± 6.1 | 141.5 ± 30.4 | |
| Eosinophils (x103) | 0.3 ± 0.0 | 0.5 ± 0.5 | 1.6 ± 0.0 | 1.2 ± 1.1 | 0.0 ± 0.0 | 1.9 ± 1.5 | 0.1 ± 0.1 | 0.07 ± 0.07 | 0.7 ± 0.6 | 3.2 ± 2.9 | |
| Lymphocytes (x103) | 2.1 ± 0.4 | 2.0 ± 0.4 | 3.8 ± 1.0 | 18.4 ± 3.8 | 1.4 ± 0.4 | 2.8 ± 0.6 | 5.0 ± 1.3 | 2.0 ± 1.0 | 1.6 ± 0.5 | 5.8 ± 2.4 | |
| Total BAL cells (x103) | 95.9 ± 5.8 | 94.1 ± 6.9 | 85.8 ± 11.6 | 154.7 ± 16.0* | 62.5 ± 3.9 | 79.5 ± 4.9 | 108.8 ± 13.0 | 104.6 ± 25.0* | 107.9 ± 6.0 | 173.6 ± 28.6**# | |
BAL fluid counts in mice. 1, 3 and 28 days post-exposure to 18 μg, 54 μg and 162 μg NanoTiO2, 54 μg, 162 μg and 486 μg sanding dusts and control mice. *, **, ***: Statistically significant compared to control mice at the 0.5, 0.01 and 0.001 level, respectively. #: Statistically significant difference between the two paints at the 0.05 level