Fig. 5. The antiallodynic effect of AM 1241 in morphine withdrawn rats is attenuated by CB2- (AM 630) but not CB1- (AM 251) antagonist.
Male Sprague-Dawley rats (6 in each group) received drug treatment twice daily for 6 days. Mean baseline paw withdrawal thresholds were measured in naïve animals (dotted line; n=48) and 96 h after the last injection using Von Frey filaments.