Figure 2.

CNS (third ICV) ghrelin delivery increases the rewarding value of sucrose in a PR ratio operant conditioning model. The number of responses on the active lever (a) and the number of 45 mg sucrose rewards obtained (b) are significantly increased by third ICV ghrelin injection for the 120-minute period of operant testing. Short-term intake of freely available chow is also increased by IP ghrelin injection (c). Data represent the mean ± SEM, n = 13, *P < 0.05, **P < 0.005 from vehicle, post hoc Tukey analysis