Table 2. Association of sex-specific quartiles of coronary artery calcium with cognitive domains and dementia: the AGES-Reykjavik Study.

	Coronary Artery Calcium Sex-specific Quartiles				p^*	p linear trend
	1^st	2^nd	3^rd	4^th	p^*	p linear trend
Adjusted means (95% Confidence Limits)
Memory^†
Adjusted for age	0.04 (−0.02; 0.10)	0.02 (−0.04; 0.08)	−0.005 (−0.06; 0.05)	−0.07 (−0.13; −0.01)	0.07	0.01
Model 1	0.03 (−0.03; 0.08)	0.01 (−0.04; 0.07)	0.000 (−0.06; 0.06)	−0.05 (−0.11; 0.005)	0.24	0.06
Model 2	0.02 (−0.05; 0.09)	0.01 (−0.06; 0.08)	0.001 (−0.07; 0.07)	−0.04 (−0.11; 0.03)	0.56	0.20
Speed of processing^†
Adjusted for age	0.08 (0.02; 0.14)	0.04 (−0.01; 0.10)	−0.01 (−0.07; 0.04)^‡	−0.09 (−0.15; −0.04)^¶	0.0002	<.0001
Model 1	0.06 (0.01; 0.12)	0.03 (−0.02; 0.09)	−0.01 (−0.06; 0.04)	−0.08 (−0.13; −0.03)^‖	0.002	0.0001
Model 2	0.04 (−0.02; 0.11)	0.02 (−0.05; 0.08)	−0.03 (−0.09; 0.04)	−0.09 (−0.15; −0.002)^§	0.01	0.001
Executive function^†
Adjusted for age	0.07 (0.02; 0.14)	0.03 (−0.03; 0.09)	−0.03 (−0.08; 0.03)^‡	−0.08 (−0.14; −0.02)^§	0.002	0.0001
Model 1	0.07 (0.01; 0.12)	0.02 (−0.03; 0.08)	−0.03 (−0.08; 0.03)^‡	−0.06 (−0.12; −0.006)^§	0.01	0.0009
Model 2	0.08 (0.01; 0.15)	0.04 (−0.02; 0.11)	0.00 (−0.07; 0.07)	−0.02 (−0.09; 0.05)^‡	0.09	0.01
Odds Ratios (95% Confidence Intervals)
Dementia
Adjusted for age	1 (ref)	1.75 (0.97; 3.16)	1.95 (1.10; 3.46)^‡	2.43 (1.39; 4.22)^§	0.02	0.002
Model 1	1 (ref)	1.85 (1.02; 3.35)^‡	2.03 (1.14; 3.61)^‡	2.47 (1.42; 4.32)^§	0.02	0.002
Model 2	1 (ref)	1.76 (0.97; 3.21)	1.95 (1.09; 3.50)^‡	2.34 (1.31; 4.19)^§	0.04	0.005

Overall difference between the four quartiles;

^†

Demented subjects (N=165) excluded;

Comparison to the first sex-specific quartile:

^‡

p<0.05

^§

p<0.01

^‖

p<0.001

^¶

p<0.0001.

Model 1: Adjusted for age, education level and presence of depressive symptoms;

Model 2: model 1 + ever smoker, prevalent coronary heart disease, current hypertension and diabetes and mid-life systolic pressure and total cholesterol.