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p53 deficiency rescues cellular apoptosis in acd mutant embryos. Immunofluorescence for cleaved caspase-3 (Casp-3) shows rare apoptotic cells in E10.5 wildtype (acd/+, p53+/+ embryo tissue sections (A–C). A significant increase in Casp-3 staining is observed in acd/acd, p53+/+ embryos (D–F). Only occasional Casp-3 positive cells are observed in acd/acd, p53−/− embryos (G–I), demonstrating rescue of apoptosis by p53 deficiency. Scale bars represent 100 μm.
