Figure 1.
Crystal structure of (R)-naproxen within the mCOX-2 active site. (a) Stereoview of (R)-naproxen (green sticks) bound in the COX-2 active. The simulated annealing omit map (Fo-Fc) contoured at 3σ is displayed in the vicinity of (R)-naproxen. Protein residues are shown in cyan sticks. (b) Stereoview of the active site of the (R)-naproxen-COX-2 complex (green sticks) overlaid with the (S)-naproxen-COX-2 complex (grey sticks).