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Binding of (R)-flurbiprofen within the mCOX-2 active site. (a) Crystal structure of (R)-flurbiprofen (magenta) bound in the active site of mCOX-2 (cyan). The simulated annealing omit map (Fo-Fc) contoured at 3σ is shown surrounding (R)-flurbiprofen. (b) Comparison of the concentration-dependence of (R)-flurbiprofen inhibition of 2-AG oxygenation by wild-type or mutant mCOX-2s. Inhibition assays were performed as described under Methods. The data points (n=3) represent the mean ± SEM.
