Figure 3.
Analysis of DRGs. (a) Immunostaining and fluorescent imaging of neurons and glia from dissociated E14 DRGs. Stimulated DRGs were imaged using a fluorescent TuJ1 antibody to label neurons (green), DAPI to label nuclei (blue), and fluorocoxib A to label COX-2 (red). (b) Western blot analysis of basal versus stimulated DRGs comparing enzymes involved in endocannabinoid metabolism and prostaglandin synthesis. (c) LC-MS chromatographic peaks and SRM transitions for prostaglandins derived from AA, AEA, and 2-AG isolated from DRGs.