Figure 4.

Inhibition of eicosanoid synthesis in stimulated DRGs by (R)-flurbiprofen, (R)-naproxen, and (R)-ibuprofen. Product formation was monitored following the oxygenation of AA, 2-AG, and AEA by COX-2 to form PGs (−), PG-Gs (- -), and PG-EAs (• •) in DRGs. IC₅₀’s were calculated using a non-linear regression. The data points represent percent inhibition with respect to control of two sets of three DRG culture plates from two independent DRG preparations for each (R)-profen. The data points (n=6) represent the mean ± SEM.